![]() Although such findings suggest the presence of potentially cross-sensitising and cross-reacting proteins between different members of the Anacardiaceae, no (cross-reactive) allergenic proteins for pink peppercorn, mango, or sumac have been identified as yet. However, mango-cashew nut cross-sensitisation seems to be of less clinical relevance as only few cases have been reported of mango allergic individuals co-sensitised to pistachio or cashew apple fruit. Mango has shown to be an important cross-reacting food for patients suffering from the “celery-mugwort-spice syndrome” and “latex-fruit syndrome”, partly caused by the Bet v 1 and 2-like type allergens. Recent case reports describing the incidence of cashew nut-allergic patients experiencing anaphylaxis after consumption of pink peppercorn or sumac emphasise the potential risk of cross-reactivity among different members of the Anacardiaceae family. Mango, pink peppercorn (often included in peppercorn blends and seasoning mixes), and the Middle Eastern spice sumac are also phylogenetically classified as Anacardiaceae. The clinical relevance of this widespread cross-sensitisation is unknown. In this study, putative novel allergens were identified in cashew, pistachio, and pink peppercorn, which may pose factors that underlie the observed cross-sensitivity to these species. Conclusions: Results demonstrate the in vitro presence of IgE cross-sensitisation in children towards multiple Anacardiaceae species. In addition, a putative luminal binding protein was identified, which, among others, may be involved in cross-reactivity between several Anacardiaceae species. In pink peppercorn, putative albumin- and legumin-type seed storage proteins were found to cross-react with serum of cashew nut-sensitised subjects in vitro. Subjects co-sensitised to Anacardiaceae species displayed a different allergen recognition pattern than subjects sensitised to common tree nuts. Of these, 50% were mono-sensitised to cashew nuts, 19% were co-sensitised to Anacardiaceae species, and 31% were co-sensitised to tree nuts. Results: From the 56 subjects analysed, 36 were positive on dot blot for cashew nut (63%). ![]() Allergen cross-reactivity patterns between Anacardiaceae species were subsequently examined by SDS-PAGE and immunoblot inhibition, and IgE-reactive allergens were identified by LC-MS/MS. Method: Sera from children with a suspected cashew nut allergy ( n = 56) were assessed for IgE sensitisation to common tree nuts, mango, pink peppercorn, and sumac using dot blot technique. We aimed to determine IgE cross-sensitisation and cross-reactivity profiles in cashew nut-sensitised subjects, towards botanically related proteins of other Anacardiaceae family members and related tree nut species. Objectives: Cashew nut allergic individuals may cross-react to foods that are phylogenetically related to cashew. IgE cross-reactivity between cashew and pistachio nut is well described however, the ability of cashew nut-specific IgE to cross-react to common tree nut species and other Anacardiaceae, like mango, pink peppercorn, or sumac is largely unknown. Background: Allergic sensitisation towards cashew nut often happens without a clear history of eating cashew nut. ![]()
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![]() ![]() ![]() If you're looking to do a new PC build, finding the right PC case is essential, but it is also going to be determined by the components you plan on including in the PC. Why you can trust TechRadar We spend hours testing every product or service we review, so you can be sure you’re buying the best. ![]() Take a look at our picks of the best PC cases below. We’ve built plenty of PCs ourselves so know what to look for when it comes to excellent PC cases. There are a lot of options out there, but we can help you narrow down the choices to find something that works for you. It's time you can get started on building your PC, and properly house and protect those vital components. So, while there may be some nice looking cases with RGB lighting and a glass side panel, if the cooling isn’t up to par, it’s not worth the investment. All those components inside – motherboard, processor, graphics card or RAM – generate heat, particularly when running demanding tasks, and the last thing you want is your PC to experience thermal throttling or get damaged from being too hot. More importantly, quality PC cases prioritize airflow to keep those expensive internals cool. After all, you don’t want to have to replace an expensive GPU because the PC case you invested in does a bad job of keeping out cat hair, dust, and other debris that may linger around your desk space. So, when building your own computer or gaming PC, you want to get something that is of great quality and does its job right. ![]() ![]() ![]() Frame Advantage: Full coverage for big heads without looking bulky or chunky.Easily my favorite lens of the three I tested. Great for fishing freshwater, bird watching, hiking with uneven footing, and mid-summer deer scouting. Thoughts on Lens: Everything pops with incredible contrast with the green mirror lens.Frame Disadvantage: No internal hinge at temple, limiting flexibility.Frame Advantage: Most padding and grip (Hydrolite) allows for a very secure feeling without weighing them down.Thoughts on Lens: Solid everyday option of lens color.Lens Type: Polarized Polycarbonate - 580P.Frame Disadvantage: Only two frame colors to choose from.Frame Advantage: Do-it-all frame that can easily make the jump from backcountry needs to lifestyle needs.Depending on the criteria you use to determine a good pair of sunglasses, I hope the below comparison helps highlight how these three models of Costas, along with their respective lenses, stack up against one another. I’ve listed the details below, along with a distinct advantage and disadvantage for each. When comparing these three pairs, I’m taking into account primarily the frame shape, size, and fit, and secondarily the lens type and color. Each have a slightly different frame and each with a different lens. ![]() Carrying case and cleaning cloth are included.Īs previously stated, I tested three models of Costa sunglasses ( Rincondo, Slack Tide, and Rincon). Together, the case and cloth weigh 2.47 oz (70 grams). It’s easy to stash into a pocket in my hiking pack or into a car’s cupholder and go, without needing to worry about damaging the shades. I’ve used these both extensively, and the case is my go-to spot for storing the shades. The Slack Tides come with a zippered hard case and a lens cleaning cloth. I do get a little nervous taking them on and off, as the hinge doesn’t flex as much as the other models I tested, but no signs of wear or loose components at this time.Ī view through the 580P (polycarbonate) green mirror lens on the Costa Slack Tides. No immediate signs of wear or loose components at this time. In addition to my daughter’s fingers, the Slack Tides have also been with me on numerous hikes, getting dropped at least once that I recall while climbing over a downfall tree that was blocking the trail. She grabs, pulls, smudges her slobbery little fingers all over my sunglasses. While I try not to be particularly hard on sunglasses my 1-year daughter doesn’t exactly share my thinking. With this in mind, the Slack Tides fit well and are comfortable over long periods of continuous use. Prior to trying the Slack Tides, I had previously experienced some sizing issues with the Rincondos, which share a similar frame fit (regular) but was one size larger in overall frame size (large). Costa’s website has a size and fit guide for each pair of sunglasses, with the frame sizings running narrow, regular or wide (they mention that most folks go with regular) and the frame size can vary from small to extra large, which is the overall size of the lens (i.e. It can be tricky to find the right size of shades without trying them on first. A little hard to see in this photo, but the rubber grip at the nose and end of the arms is liberally applied. ![]() The Slack Tides also feature an open attachment point for certain types of retainers/straps, although the only ones I’ve used with these frames are over-the-top style retainers. The bioresin frames are lightweight, weighing in (with polycarbonate lens) at 1.02 oz (29 grams). The construction of the Slack Tides includes a generous amount of Hydrolite rubber which acts as a non-slip contact point on the nose and behind the ears (a positive) but also a one-way temple hinge that limits the overall flexibility of the frames (a negative). The Costa Slack Tides are a little more casual looking than most adventure sunglasses, but don’t let that fool you, they are fully capable shades for many outdoor pursuits. You’ll see a comparison to the other two at the end of the review.įor three warm-weather seasons, I wore the Costa Slack Tide sunglasses while fly fishing, hiking, and scouting for whitetail deer and elk, as well as everyday uses like casual bike rides. This test is for the Costa Slack Tide with Green Mirror polycarbonate lenses. Each featured a different lens and frame, allowing me to test multiple variables when considering Costa sunglasses. During the spring, summer and early autumn, I tested three different styles of Costa sunglasses ( Rincondo, Slack Tide, and Rincon). ![]() |